ChloroquineV1, Main, Exploration, bibRecord, 001127

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

Identifieur interne : 001127 ( Main/Exploration ); précédent : 001126; suivant : 001128

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

Auteurs : Phurpa Wangchuk ; Wangchuk Phurpa [Australie] ; Paul A. Keller ; Stephen G. Pyne ; Wilford Lie ; Anthony C. Willis ; Roonglawan Rattanajak ; Sumalee Kamchonwongpaisan

Source :

Journal of ethnopharmacology [ 1872-7573 ] ; 2013.

RBID : pubmed:24120516

Descripteurs français

KwdFr :
- Alcaloïdes (pharmacologie), Alcaloïdes de type berbérine (pharmacologie), Animaux, Antipaludiques (pharmacologie), Cellules Vero, Extraits de plantes (pharmacologie), Papaveraceae, Plasmodium falciparum (), Survie cellulaire.
MESH :
- pharmacologie : Alcaloïdes, Alcaloïdes de type berbérine, Antipaludiques, Extraits de plantes.
- Animaux, Cellules Vero, Papaveraceae, Plasmodium falciparum, Survie cellulaire.

English descriptors

KwdEn :
- Alkaloids (pharmacology), Animals, Antimalarials (pharmacology), Berberine Alkaloids (pharmacology), Cell Survival, Chlorocebus aethiops, Papaveraceae, Plant Extracts (pharmacology), Plasmodium falciparum (drug effects), Vero Cells.
MESH :
- chemical , pharmacology : Alkaloids, Antimalarials, Berberine Alkaloids, Plant Extracts.
- drug effects : Plasmodium falciparum.
- Animals, Cell Survival, Chlorocebus aethiops, Papaveraceae, Vero Cells.

Abstract

The aerial components of Meconopsis simplicifolia (D. Don) Walpers are indicated in Bhutanese traditional medicine for treating malaria, coughs and colds, and the infections of the liver, lung and blood. This study is to validate the ethnopharmacological uses of this plant and also identify potent antimalarial drug leads through bioassays of its crude extracts and phytochemical constituents.

DOI: 10.1016/j.jep.2013.09.052
PubMed: 24120516

Affiliations:

Australie

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.</title>
<author><name sortKey="Wangchuk, Phurpa" sort="Wangchuk, Phurpa" uniqKey="Wangchuk P" first="Phurpa" last="Wangchuk">Phurpa Wangchuk</name>
</author>
<author><name sortKey="Phurpa, Wangchuk" sort="Phurpa, Wangchuk" uniqKey="Phurpa W" first="Wangchuk" last="Phurpa">Wangchuk Phurpa</name>
<affiliation wicri:level="1"><nlm:affiliation>Menjong Sorig Pharmaceuticals, Ministry of Health, Thimphu, Bhutan; School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: phurpaw@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menjong Sorig Pharmaceuticals, Ministry of Health, Thimphu, Bhutan; School of Chemistry, University of Wollongong, Wollongong, NSW 2522</wicri:regionArea>
<wicri:noRegion>NSW 2522</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Keller, Paul A" sort="Keller, Paul A" uniqKey="Keller P" first="Paul A" last="Keller">Paul A. Keller</name>
</author>
<author><name sortKey="Pyne, Stephen G" sort="Pyne, Stephen G" uniqKey="Pyne S" first="Stephen G" last="Pyne">Stephen G. Pyne</name>
</author>
<author><name sortKey="Lie, Wilford" sort="Lie, Wilford" uniqKey="Lie W" first="Wilford" last="Lie">Wilford Lie</name>
</author>
<author><name sortKey="Willis, Anthony C" sort="Willis, Anthony C" uniqKey="Willis A" first="Anthony C" last="Willis">Anthony C. Willis</name>
</author>
<author><name sortKey="Rattanajak, Roonglawan" sort="Rattanajak, Roonglawan" uniqKey="Rattanajak R" first="Roonglawan" last="Rattanajak">Roonglawan Rattanajak</name>
</author>
<author><name sortKey="Kamchonwongpaisan, Sumalee" sort="Kamchonwongpaisan, Sumalee" uniqKey="Kamchonwongpaisan S" first="Sumalee" last="Kamchonwongpaisan">Sumalee Kamchonwongpaisan</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:24120516</idno>
<idno type="pmid">24120516</idno>
<idno type="doi">10.1016/j.jep.2013.09.052</idno>
<idno type="wicri:Area/PubMed/Corpus">000322</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000322</idno>
<idno type="wicri:Area/PubMed/Curation">000322</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000322</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000340</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000340</idno>
<idno type="wicri:Area/Ncbi/Merge">000217</idno>
<idno type="wicri:Area/Ncbi/Curation">000217</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000217</idno>
<idno type="wicri:Area/Main/Merge">001128</idno>
<idno type="wicri:Area/Main/Curation">001127</idno>
<idno type="wicri:Area/Main/Exploration">001127</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.</title>
<author><name sortKey="Wangchuk, Phurpa" sort="Wangchuk, Phurpa" uniqKey="Wangchuk P" first="Phurpa" last="Wangchuk">Phurpa Wangchuk</name>
</author>
<author><name sortKey="Phurpa, Wangchuk" sort="Phurpa, Wangchuk" uniqKey="Phurpa W" first="Wangchuk" last="Phurpa">Wangchuk Phurpa</name>
<affiliation wicri:level="1"><nlm:affiliation>Menjong Sorig Pharmaceuticals, Ministry of Health, Thimphu, Bhutan; School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: phurpaw@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menjong Sorig Pharmaceuticals, Ministry of Health, Thimphu, Bhutan; School of Chemistry, University of Wollongong, Wollongong, NSW 2522</wicri:regionArea>
<wicri:noRegion>NSW 2522</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Keller, Paul A" sort="Keller, Paul A" uniqKey="Keller P" first="Paul A" last="Keller">Paul A. Keller</name>
</author>
<author><name sortKey="Pyne, Stephen G" sort="Pyne, Stephen G" uniqKey="Pyne S" first="Stephen G" last="Pyne">Stephen G. Pyne</name>
</author>
<author><name sortKey="Lie, Wilford" sort="Lie, Wilford" uniqKey="Lie W" first="Wilford" last="Lie">Wilford Lie</name>
</author>
<author><name sortKey="Willis, Anthony C" sort="Willis, Anthony C" uniqKey="Willis A" first="Anthony C" last="Willis">Anthony C. Willis</name>
</author>
<author><name sortKey="Rattanajak, Roonglawan" sort="Rattanajak, Roonglawan" uniqKey="Rattanajak R" first="Roonglawan" last="Rattanajak">Roonglawan Rattanajak</name>
</author>
<author><name sortKey="Kamchonwongpaisan, Sumalee" sort="Kamchonwongpaisan, Sumalee" uniqKey="Kamchonwongpaisan S" first="Sumalee" last="Kamchonwongpaisan">Sumalee Kamchonwongpaisan</name>
</author>
</analytic>
<series><title level="j">Journal of ethnopharmacology</title>
<idno type="eISSN">1872-7573</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alkaloids (pharmacology)</term>
<term>Animals</term>
<term>Antimalarials (pharmacology)</term>
<term>Berberine Alkaloids (pharmacology)</term>
<term>Cell Survival</term>
<term>Chlorocebus aethiops</term>
<term>Papaveraceae</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plasmodium falciparum (drug effects)</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alcaloïdes (pharmacologie)</term>
<term>Alcaloïdes de type berbérine (pharmacologie)</term>
<term>Animaux</term>
<term>Antipaludiques (pharmacologie)</term>
<term>Cellules Vero</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Papaveraceae</term>
<term>Plasmodium falciparum ()</term>
<term>Survie cellulaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Alkaloids</term>
<term>Antimalarials</term>
<term>Berberine Alkaloids</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium falciparum</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Alcaloïdes</term>
<term>Alcaloïdes de type berbérine</term>
<term>Antipaludiques</term>
<term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Survival</term>
<term>Chlorocebus aethiops</term>
<term>Papaveraceae</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Papaveraceae</term>
<term>Plasmodium falciparum</term>
<term>Survie cellulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The aerial components of Meconopsis simplicifolia (D. Don) Walpers are indicated in Bhutanese traditional medicine for treating malaria, coughs and colds, and the infections of the liver, lung and blood. This study is to validate the ethnopharmacological uses of this plant and also identify potent antimalarial drug leads through bioassays of its crude extracts and phytochemical constituents.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><noCountry><name sortKey="Kamchonwongpaisan, Sumalee" sort="Kamchonwongpaisan, Sumalee" uniqKey="Kamchonwongpaisan S" first="Sumalee" last="Kamchonwongpaisan">Sumalee Kamchonwongpaisan</name>
<name sortKey="Keller, Paul A" sort="Keller, Paul A" uniqKey="Keller P" first="Paul A" last="Keller">Paul A. Keller</name>
<name sortKey="Lie, Wilford" sort="Lie, Wilford" uniqKey="Lie W" first="Wilford" last="Lie">Wilford Lie</name>
<name sortKey="Pyne, Stephen G" sort="Pyne, Stephen G" uniqKey="Pyne S" first="Stephen G" last="Pyne">Stephen G. Pyne</name>
<name sortKey="Rattanajak, Roonglawan" sort="Rattanajak, Roonglawan" uniqKey="Rattanajak R" first="Roonglawan" last="Rattanajak">Roonglawan Rattanajak</name>
<name sortKey="Wangchuk, Phurpa" sort="Wangchuk, Phurpa" uniqKey="Wangchuk P" first="Phurpa" last="Wangchuk">Phurpa Wangchuk</name>
<name sortKey="Willis, Anthony C" sort="Willis, Anthony C" uniqKey="Willis A" first="Anthony C" last="Willis">Anthony C. Willis</name>
</noCountry>
<country name="Australie"><noRegion><name sortKey="Phurpa, Wangchuk" sort="Phurpa, Wangchuk" uniqKey="Phurpa W" first="Wangchuk" last="Phurpa">Wangchuk Phurpa</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001127 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001127 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:24120516
   |texte=   A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24120516" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.